Dr. Haifan Lin

A Drosophila chromatin factor interacts with the piRNA mechanism in niche cells to regulate germline stem cell self-renewal

Capturing the Cloud: UAP56 in Nuage Assembly and Function

The nuage is a hazy electron-dense structure unique to germ cells and is enriched in components of the piRNA pathway. Although the nuage is cytoplasmic, Zhang et al. now show that it is organized by an intranuclear protein, UAP56.

Translational repression: A duet of Nanos and Pumilio

Recent studies have shed new light on translational repression by Nanos and Pumilio proteins. The ancestral function of this repression mechanism appears to be in early germline development; later, species-specific applications in embryonic patterning and spermatogenesis-oogenesis switching evolved.

Cell biology.

Professors Christopher Burd, Michael Caplan (Cellular & Molecular Physiology), Lynn Cooley (Genetics), Peter Cresswell (Immunobiology), Pietro De Camilli, Jorge Galán (Microbial Pathogenesis), Fred Gorelick, Carl Hashimoto (Emeritus), James Jamieson, Diane Krause (Laboratory Medicine), Thomas Lentz (Emeritus), Haifan Lin, Vincent Marchesi (Pathology), Mark Mooseker (Molecular, Cellular & Develo...

Purified primitive human hematopoietic progenitor cells with long-term in vitro repopulating capacity adhere selectively to irradiated bone marrow stroma

We enriched bone marrow cells from 10 normal individuals for primitive hematopoietic progenitors using a two-step technique, and examined resultant primitive progenitors for their in vitro long-term repopulating capacity and their ability to adhere to irradiated stroma. Immunomagnetic depletion of mature myeloid and lymphoid progenitors resulted in a lineage-negative (Lin-) cell population. Sub...